April 12, 2015: Hillary Clinton launches her second presidential campaign.

Clinton launches her 2016 presidential campaign with a YouTube video on April 12, 2015. (Credit: CNN)

Clinton launches her 2016 presidential campaign with a YouTube video on April 12, 2015. (Credit: CNN)

She narrowly lost the Democratic nomination to Barack Obama in 2008. Due to her long and prominent political career, she immediately establishes herself as the frontrunner in the race for the Democratic nomination. (The New York Times, 4/13/2015) 

She resigns from the board of directors of the Clinton Foundation on the same day to avoid conflict of interest issues. (Politico, 4/12/2015)